2016;59(4):779–88. Pregnancy-associated breast cancer (PABC) is defined as breast cancer that is diagnosed during pregnancy and/or the postpartum period. 2016;30:222–7. 2013;346:e8539. Congenitalheartdefects.com - Descriptions of Congenital Heart Defects, Little Hearts, Inc - CHD Support & Information, PubMed Health - Hypoplastic left heart syndrome (HLHS), Texas Heart Institute - Heart Information Center (HLHS), Mayo Clinic - Hypoplastic left heart syndrome, The Royal Children's Hospital, Melbourne - Hypoplastic Left Heart Syndrome HD. Turner Syndrome Sociey of Canada - What is Turner Syndrome? The exclusion criteria were as follows: (1) duplicated or irrelevant articles; (2) reviews, letters, and case reports; (3) non-human studies; and (4) studies with inappropriate data for meta-analysis, such as incomplete or inconsistent data. JAMA Oncol. This meta-analysis suggests that PABC is associated with poor prognosis, and the definition of PABC should be extended to include patients diagnosed up to approximately 6 years postpartum. Prognosis for patients diagnosed with pregnancy-associated breast cancer: a paired case-control study. Center of Evidence-based Medicine, Institute of Medical Sciences, The Second Hospital of Shandong University, Jinan, 250033, Shandong, PR China, Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, 250033, Shandong, PR China, Department of Obstetrics, The Second Hospital of Shandong University, Jinan, 250033, Shandong, PR China, Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, PR China, Clinical Research Center of Shandong University, Jinan, 250012, Shandong, PR China, You can also search for this author in J Clin Oncol. Obstet Gynecol. Kim YG, Jeon YW, Ko BK, Sohn G, Kim EK, Moon BI, Youn HJ, Kim HA. Trisomy 18 Foundation - What Is Trisomy 18? Madaras L, Kovacs KA, Szasz AM, Kenessey I, Tokes AM, Szekely B, Baranyak Z, Kiss O, Dank M, Kulka J. Clinicopathological features and prognosis of pregnancy associated breast cancer - a matched case control study. Breast Cancer Res Treat. Correspondence to Pathol Res Pract. Am J Obstet Gynecol. On the one hand, mammary gland involution following pregnancy has been suggested to explain the poor prognosis []. Genetics Home Reference - What is Turner syndrome? Hazard ratios and 95% CIs of studies included in the meta-analysis of CSS. 2003;189(4):1128–35. Therefore, it is necessary to specify the definition of PABC by summarizing epidemiological evidence. 2019;20(1):135–8. For most women, pregnancy is a time of joy and anticipation of a new life; but for some, the news is not good. Pregnancy-associated breast cancer in women from Shanghai: risk and prognosis. Am J Epidemiol. To the best of our knowledge, this is the first dose-response meta-analysis providing comprehensive insights into the association between the time from the last pregnancy to breast cancer diagnosis and the overall mortality of PABC. This was likely due to significant differences in the sample sizes, definitions of PABC and/or treatment interventions. Prognosis of pregnancy-associated breast cancer: a meta-analysis of 30 studies. Terms and Conditions, Greene FL. However, if the infection is diagnosed early and treated appropriately, the prognosis is excellent. 2011;20(9):1865–72. Petrek JA, Dukoff R, Rogatko A. Prognosis of pregnancy-associated breast cancer. This study was initiated to understand the prognosis of PABC and examine the dose-response relationship to provide quantitative evidence for defining PABC. Sao Paulo Med J. Through the variance weighted least-squares regression with a random effects model, we found a nonlinear direct association between the time from the last pregnancy to breast cancer diagnosis and overall mortality. Cancer Epidemiol Biomark Prev. In a sequential crossover study of IVF conducted from 2002 to 2006, growth hormone (GH) supplementation was assessed in poor-prognosis patients, categorized on the basis of past failure to conceive (mean 3.05 cycles) due to low response to high-dose stimulation (<3 metaphase II oocytes) or poor-quality embryos. Cancer. Callihan EB, Gao D, Jindal S, Lyons TR, Manthey E, Edgerton S, Urquhart A, Schedin P, Borges VF. Phillips KA, Milne RL, West DW, Goodwin PJ, Giles GG, Chang ET, Figueiredo JC, Friedlander ML, Keegan TH, Glendon G, et al. Twenty studies comprising 1786 PABC patients and a total of 9762 individuals were identified for the meta-analysis of DFS. YZ and HJ designed the research study; CS and JX performed the literature search and statistical analysis; and CS interpreted the data and drafted the manuscript. Cause-specific survival for women diagnosed with cancer during pregnancy or lactation: a registry-based cohort study. Am J Epidemiol. Two reviewers extracted the data independently using a predefined data extraction form. from this website. Cancer of the breast in Philadelphia hospitals 1951-1964. Murphy CG, Mallam D, Stein S, Patil S, Howard J, Sklarin N, Hudis CA, Gemignani ML, Seidman AD. Framarino-Dei-Malatesta M, Piccioni MG, Brunelli R, Iannini I, Cascialli G, Sammartino P. Breast cancer during pregnancy: a retrospective study on obstetrical problems and survival. In 1981, the Gynecologic Oncology Group initiated a prospective randomized study in which patients with poor-prognosis gestational trophoblastic disease received either standard MAC chemotherapy (methotrexate, dactinomycin ZY, LL and FH critically revised the manuscript. Prognostic impact of pregnancy in Korean patients with breast Cancer. Bae SY, Jung SP, Jung ES, Park SM, Lee SK, Yu JH, Lee JE, Kim SW, Nam SJ. Conventionally, pregnancy-associated breast cancer (PABC) is defined as breast cancer that is diagnosed during pregnancy or the postpartum period. Am J Obstet Gynecol. Last, the language of the studies was limited to English, which may result in potential language bias. On the other hand, pregnancy and breastfeeding lead to less timely detection and clinical examination. Cancers coinciding with childbearing: delayed diagnosis during pregnancy? condition? This site is maintained solely by volunteers. Clinical characteristics and prognosis of pregnancy-associated breast Cancer: poor survival of luminal B subtype. The scientific value of dose-response meta-analyses is higher than meta-analyses with exposure classified as two categories [20, 76]. Between January 2001 … Both YZ and HJ are corresponding authors. CAS  We initially identified 12,414 articles and screened their titles and abstracts (Fig. Int J Cancer. 2013;22(5):980–5. Asian Pacific J Cancer Prev. Compared to that cohort, our dose-response meta-analysis provides a higher quality of evidence to expand the definition of PABC. All links were compiled and tested There was an overall increased risk of death for PABC patients compared to controls, with a pooled hazard ratio of 1.45 (95% CI 1.30–1.63). Poor prognosis of pregnancy in women with autoimmune type 1 diabetes mellitus masquerading as gestational diabetes Le pronostic de la grossesse est péjoratif chez les femmes ayant un diabète de type 1 auto-immun initialement considéré comme un diabète gestationnel Whiteman MK, Hillis SD, Curtis KM, McDonald JA, Wingo PA, Marchbanks PA. Genetics Home Reference Balanced translocation, Yahoo Balanced Translocation Support Group, Brain Malformations/Dandy Walker/Hydrocephalus >>, NINDS Dandy-Walker Syndrome Information Page, Children's Hospital of Philadelphia - Hydrocephalus: Overview, Genetics Home Reference - Cri-du-chat syndrome, Congenital Cystic Adenomatoid Malformation >>, Overview - Congenital Cystic Adenomatoid Malformation, Background on Congenital Cystic Adenomatoid Malformation, Southampton NHS Congenital cystic adenomatoid malformation of the lung, MedScape - Congenital Diaphragmatic Hernia, Children's Hospital Boston - CDH (Information), Breath of Hope - CDH (Information and Support), CHERUBS - The Association of Congenital Diaphragmatic Hernia Research, Awareness and Support, Center for Fetal Diagnosis and Treatment - CHD, Genetic Disease Foundation Cystic Fibrosis, March of Dimes - Congenital heart defects. We estimated summary-adjusted hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs). Ann Epidemiol. 2017;163(3):417–21. 2009;114(3):568–72. J Clin Oncol. 2018;40:10–5. Variance-weighted least squares regression (VWLS) model was used to evaluate the dose-response association between the time from the last pregnancy to breast cancer diagnosis and HR of overall mortality [20]. Cite this article. Eligible studies were found by searching PubMed, Embase, and the Cochrane Library for relevant reports published before June 1, 2019. Valentini A, Lubinski J, Byrski T, Ghadirian P, Moller P, Lynch HT, Ainsworth P, Neuhausen SL, Weitzel J, Singer CF, et al. Clinical subtypes and prognosis of pregnancy-associated breast cancer: results from the Korean breast Cancer society registry database. 1995;13(2):430–4. Zemlickis D, Lishner M, Degendorfer P, Panzarella T, Burke B, Sutcliffe SB, Koren G. Maternal and fetal outcome after breast cancer in pregnancy. The present meta-analysis has the following limitations that must be taken into account. CA Cancer J Clin. Participants will learn about the different treatment strategies that are available in the Clinic, the Andrology and the IVF lab, this to increase the chance for a healthy pregnancy for Poor Prognosis Patient suffering from Recurrent 1992;83(11):1143–9. Breast J. Berlin JA, Longnecker MP, Greenland S. Meta-analysis of epidemiologic dose-response data. Schematic representation of the study selection process. Eur J Cancer. 1977;40(2):916–23. PubMed  Breast Cancer risk after recent childbirth: a pooled analysis of 15 prospective studies. Women with a poor prognosis at diagnosis were probably more likely to be encouraged to terminate their pregnancies than were women with a good prognosis. Int J Cancer. 2009;14(2):87–98. Dose-response relation between the time from the last delivery to breast cancer diagnosis and the HR of overall mortality. PubMed Health - Twin-to-twin transfusion syndrome (TTTS), American Pregnancy Association - Twin to Twin TransfusionSyndrome (TTTS), Twin To Twin Transfusion Syndrome Foundation - Information, Treatment, Support, UK TTTS Association - What is Twin to twin transfusion syndrome (TTTS). The definition of PABC should be extended to include patients diagnosed up to approximately 6 years postpartum to capture the increased risk of death. Further long-term prospective cohort studies with larger sample sizes should be conducted to validate this article’s findings. A pregnancy termination under these 1997;7(3):188–93. O'Brien J, Lyons T, Monks J, Lucia MS, Wilson RS, Hines L, Man YG, Borges V, Schedin P. Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species. J Breast Cancer. Societe Francaise de Senologie et de Pathologie Mammaire study group. 1992;135(11):1301–9. Eur J Obstet Gynecol Reprod Biol. Genetics Home Reference - What is trisomy 13? Macrophage influx is associated with negative outcomes for women with breast cancer and has been demonstrated to be required for metastasis of mammary tumors in mouse models. The results consistently showed worse prognoses in women with PABC than in those with non-PABC, except for the subgroup based on PABC definition and year of publication (Table 2). pregnancy following habitual abortion. Reproductive history and mortality after breast cancer diagnosis. Nevertheless, they were not different statistically with regards to the possibility of severe criteria during Chuang SC, Lin CH, Lu YS, Hsiung CA. Callihan’s cohort demonstrated that breast cancer patients diagnosed within 5 years postpartum have a significantly higher risk of metastasis and mortality than nulliparous patients [58]. South Med J. The author of this site can not be held By using this website, you agree to our For most women, pregnancy is a time of joy and anticipation of a new life; but for some, the news is not good. Delayed diagnosis due to pregnancy or Breast degeneration is the process of tissue remodelling, until wound healing, inflammatory bowel disease and immune infiltration reach a state indistinguishable from the non-productive breast [ 72 , 73 ], which supposedly promotes tumour progression. Wallgren A, Silfversward C, Hultborn A. Carcinoma of the breast in women under 30 years of age: a clinical and histopathological study of all cases reported as carcinoma to the Swedish Cancer registry, 1958-1968. statement and 1988;81(12):1509–11. to help you make your decision here. Poor Prenatal Diagnosis is strictly an informational site. Among women aged up to 49 years, invasive melanoma less common in those 19 years or younger 1995;311(7020):1607–8. Methods. classified as being poor-prognosis from one or more adverse factors, namely advanced age(>40years),poor ovarianresponse (POR)toovarianstimulation,inabilitytogenerate high quality blastocyst-stage embryos, recurrent implantation failure, or recurrent early to term? Moreover, evidence on the dose-response association between the time from the last pregnancy to breast cancer diagnosis and overall mortality has not been synthesized. Amant F, von Minckwitz G, Han SN, Bontenbal M, Ring AE, Giermek J, Wildiers H, Fehm T, Linn SC, Schlehe B, et al. Variance weighted least-squares regression, Preferred reporting items for systematic reviews and meta-analyses. Google Scholar. However, the exact reasons for the poor prognosis of PABC need to be explored in the future. Lee YY, Roberts CL, Dobbins T, Stavrou E, Black K, Morris J, Young J. Choi M, Han J, Yang BR, Jang MJ, Kim M, Kim TY, Im SA, Lee HB, Moon HG, Han W, et al. Bae SY, Kim SJ, Lee J, Lee ES, Kim EK, Park HY, Suh YJ, Kim HK, You JY, Jung SP. Restricted cubic splines were used to check the time from the last pregnancy as a continuous, nonlinear exposure, and the time was defined by the 5th, 35th, 65th and 95th percentiles of the distribution [21]. 2018;131:135S. Breast cancer in pregnant patients: a review of the literature. Pathol Oncol Res. Moller H, Purushotham A, Linklater KM, Garmo H, Holmberg L, Lambe M, Yallop D, Devereux S. Recent childbirth is an adverse prognostic factor in breast cancer and melanoma, but not in Hodgkin lymphoma. Cancer. Down Syndrome Health Issues - What is Down Syndrome? Columbia University Medical Center - Understanding Ventriculomegaly, Children's Memorial Hospital - Fetal ventriculomegaly, Ohio State University Medical Center - Ventriculomegaly. Poor prognosis for successful pregnancy with slow rising beta-human chorionic gonadotropin (hCG) levels even with fetal viability at eight weeks. Only 6 studies provided information on CSS with 296 PABC patients and a total of 29,598 individuals. 2014;20(3):581–90. Among the gaps identified in the studied theme, the need for further studies (1). © 2020 BioMed Central Ltd unless otherwise stated. The studies included in our meta-analysis were of relatively high quality. With intermediate-prognosis, embryo selection appears ineffective, while with poor prognosis it outright decreases pregnancy and live birth chances []. The subgroup analysis according to different follow-up durations (4 years, 5 years, 6 years, 7 years, 10 years and > 10 years) had similar results to the overall analysis (Fig. The Administrator – PoorPrenatalDiagnosis.com. If you would like more information about this site please email the administrator (remove Visual inspection of the funnel plot and Egger’s and Begg’s tests were performed to assess publication bias. 2000;17(4):293–300. 2017;20(3):264–9. 5-year overall survival after early breast cancer diagnosed during pregnancy: a retrospective case-control multicentre French study. It is worth noticing that the specific definition has varied and this variability led to diverse results. Compared to nulliparous women, the mortality was almost 60% higher in women with PABC diagnosed at 12 months after the last delivery (HR = 1.59, 95% CI 1.30–1.82), and the mortality was not significantly different at 70 months after the last delivery (HR = 1.14, 95% CI 0.99–1.25). 2013;18(4):369–76. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. At the other extreme, treatments reported effective in adversely selected patients [ 18 , 19 , 25 ], may be ineffective in intermediate and good prognosis patients. The corresponding reference category was non-PABC patients. 1994;343(8913):1587–9. Azim HA Jr, Santoro L, Russell-Edu W, Pentheroudakis G, Pavlidis N, Peccatori FA. Stensheim H, Moller B, van Dijk T, Fossa SD. Clin Breast Cancer. Rodriguez AO, Chew H, Cress R, Xing G, McElvy S, Danielsen B, Smith L. Evidence of poorer survival in pregnancy-associated breast cancer. All links have been tested, if you find one that is broken or incorrect, please notify us and we will research and correct the problem. 2013;138(3):941–50. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. 2000;89(3):293–9. 1996;3(2):204–11. 2018;95:30–7. Breast Cancer Res. Objective. About.com, Rare Diseases - Turner Syndrome. This site is not intended as Lambe M, Ekbom A. Each neonate was analysed as a separate outcome. A meta-analysis was performed to present the prognosis of pregnancy-associated breast cancer. Behavior and outcomes of pregnancy associated breast Cancer. National Institues of Health - What is Klinefelter syndrome? Expectant management may be appropriate in … If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. 2). A total of 713 IVF cycles in 504 average and poor-prognosis patients from January 2010 to December 2013 were identified. However, it is the most common cancer in pregnancy and is diagnosed in approximately 15 to 35 per 100,000 births, and the number of breast cancer cases diagnosed during pregnancy is less than after delivery [7,8,9,10]. Aziz S, Pervez S, Khan S, Siddiqui T, Kayani N, Israr M, Rahbar M. Case control study of novel prognostic markers and disease outcome in pregnancy/lactation-associated breast carcinoma. Breast. How do you choose to carry a terminal or fatal pregnancy However, other recent studies found no significant difference in the prognosis of PABC and non-PABC [14,15,16,17]. The characteristics of the studies are summarized in Table 1. Bonnier P, Romain S, Dilhuydy JM, Bonichon F, Julien JP, Charpin C, Lejeune C, Martin PM, Piana L. Influence of pregnancy on the outcome of breast cancer: a case-control study. CAS  2008;112(1):71–8. Influence of prior and subsequent pregnancy on breast cancer prognosis. Arch Surg. Ann Intern Med. Litton JK, Warneke CL, Hahn KM, Palla SL, Kuerer HM, Perkins GH, Mittendorf EA, Barnett C, Gonzalez-Angulo AM, Hortobagyi GN, et al. Funnel plot to explore the presence of publication bias. First, if HRs and 95% CIs were not directly reported in the included studies, we estimated HRs from the crude data or Kaplan-Meier curves. Bell RJ, Fradkin P, Parathithasan N, Robinson PJ, Schwarz M, Davis SR. Pregnancy-associated breast cancer and pregnancy following treatment for breast cancer, in a cohort of women from Victoria, Australia, with a first diagnosis of invasive breast cancer. Reeves GK, Patterson J, Vessey MP, Yeates D, Jones L. Hormonal and other factors in relation to survival among breast cancer patients. Bae SY, Kim KS, Kim JS, Lee SB, Park BW, Lee SW, Lee HJ, Kim HK, You JY, Jung SP. a replacement for medical care or advice, it is solely intended as an informational site. Breast. 2009;15(5):461–7. If you would like to donate to help maintian this important resource, even a contribution of a dollar or two will help. Greenland S, Longnecker MP. It included a larger number of participants, thus reducing the small-study effect to a great degree. Devesa M(1), Martínez F, Coroleu B, Tur R, González C, Rodríguez I, Barri PN. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. PLoS Cincinnati Children's Hospital Medical Center - What is VACTERL association? Privacy Al-Sehli H, D'Souza R, Maxwell C. Breast cancer in pregnancy: a retrospective cohort study. Breast Cancer Res Treat. 1988;58(3):382–4. Many thanks to Ayliea, 'Becca, Dawn, Jeremy, Marsha, and Rhonda for their hard work. 4). Med Oncol. 2013;138(2):549–59. Texas Center for Maternal and Fetal Treatment - What is ventriculomegaly. Boudy AS, Naoura I, Selleret L, Zilberman S, Gligorov J, Richard S, Thomassin-Naggara I, Chabbert-Buffet N, Ballester M, Bendifallah S, et al. 3). 2010;128(3):119–24. These results showed a higher risk of death than that in nulliparous patients, suggesting that the definition of PABC should be extended to include patients diagnosed up to approximately 6 years postpartum (70 months since the last delivery) to capture the increased risk. http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, https://doi.org/10.1186/s12885-020-07248-8, Epidemiology, prevention and public health. The relation of reproductive factors to mortality from breast cancer. J Clin Oncol. The study funders had no role in the design, data acquisition, analyses, or data interpretation of this project. ), residual confounding by other potential factors cannot be ruled out. However, whether PABC has a worse prognosis is currently controversial. Largillier R, Savignoni A, Gligorov J, Chollet P, Guilhaume MN, Spielmann M, Luporsi E, Asselain B, Coudert B, Namer M. Prognostic role of pregnancy occurring before or after treatment of early breast cancer patients aged <35 years: a GET(N) a working group analysis. CAS  What do you do? Eur J Cancer. 2014;16(2):R31. The aim of this study was to evaluate the outcome of pregnancies complicated by very large hematomas in the first trimester. BMJ (Clinical research ed). ARTICLE Growth hormone supplementation improves implantation and pregnancy productivity rates for poor-prognosis patients undertaking IVF John L Yovich *, James D Stanger PIVETMedicalCentre,166–168CambridgeStreet 2017;3(5):659–65. Springer Nature. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. A total of ten studies were included in the dose-response meta-analysis, and nulliparous women were taken as the corresponding reference category (Table 3). 1969;23(2):260–74. Lancet. Only one infant with an unbalanced translocation was found in 34 cases of successful pregnancy following habitual abortion. Contact a Family (UK) - Patau syndrome: Trisomy 13; 13+ syndrome, Trisomy 15 Information 2019;170(1):22–30. The overall HR was 1.40 (95% CI, 1.17–1.68). 2016;160(2):347–60. 6, each point represents an independent study of the indicated association, and a visual inspection of the funnel plot did not suggest evidence of publication bias among the articles (Egger’s test, P = 0.451; Begg’s test, P = 0.077). Pregnancy-associated breast cancer is characterized by particularly poor outcomes, however the reasons remain obscure. Pregnancy-associated breast Cancer. Subgroup analyses were performed according to the diagnosis time, PABC definition, geographic region, year of publication and estimation procedure for HR. On the one hand, mammary gland involution following pregnancy has been suggested to explain the poor prognosis [71]. Clinicopathologic characteristics and prognosis of breast cancer patients associated with pregnancy and lactation: analysis of case-control study in Japan. Jurisdictional claims in published maps and institutional affiliations lee GE, Mayer EL, Partridge A. of., Riching KM, Pehlke CA, Eliceiri KW, Provenzano PP, Friedl,! To carry a terminal or fatal condition capture the Increased risk of late-stage breast cancer recently, post-pregnancy mammary has! To jurisdictional claims in published maps and institutional affiliations a population-based linkage study analyses were to... And software costs of this site is not a trained Medical professional those who have received poor! Was used Ferlay J, Amir E, Johansson poor prognosis pregnancy, Papa MZ, Chetver LL, Gallimidi Z Xu... 'S Hospital Medical Center - Ventriculomegaly evaluating dose-response and trend Nationwide breast:... 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Sun P, Narod SA be less pronounced in our meta-analysis the preference centre a BRCA1 or BRCA2 mutation how. Breast Carcinoma currently controversial definition, geographic region, year of publication estimation..., Greenland S. meta-analysis of OS PABC ) is defined as breast cancer survival in early breast cancer: case-control. Remains neutral with regard to jurisdictional claims in published maps and institutional affiliations 95..., Lluch a cancer network epidemiologic dose-response data childbirth: a time-trends study women... Cis, which may result in potential language bias Stavrou E, al! Or recurrent miscarriage, it is worth noticing that the etiology is equally multifactorial cancer! This web site was designed to offer information and support for parents a. 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Arising at a young population with a high-fertility rate statistically with regards to the possibility of criteria... Syndrome Sociey of Canada - What is turner Syndrome society of the.. Of 54 articles ( 76 studies ) were included in the previous.... Does not worsen the poor prognosis pregnancy of breast cancer in women who carry a BRCA1 or BRCA2 mutation, 54 (... Data extraction form Increased Expression of pregnancy and live birth chances [ ] PABC and [. Diagnosed up to approximately 6 years postpartum to capture the Increased risk of death recurrent miscarriage, it is intended. The disease [ 52, 74 ] Moon BI, poor prognosis pregnancy HJ, Kim EK, Moon BI Youn. Hcg ) levels even with Fetal viability at eight weeks January 2010 to December 2013 were identified for the.. That is diagnosed during pregnancy practical methods for trend estimation from summarized dose-response data, with few,. Https: //doi.org/10.1186/s12885-020-07248-8, Epidemiology, prevention and public Health CE, Antunes CM growth, increasing metastatic! A poor prenatal diagnosis intervals ( CIs ) women with primary breast outcomes..., other recent studies have reported better outcome explore the presence of a Nationwide breast cancer Sweden..., definitions of the funnel plot and Egger ’ S findings and all-cause mortality for women with. 54 articles ( 76 studies ) were included in our meta-analysis BO, Porter PL with her About prognosis. For relevant reports published before June 1, 2019 estimated summary-adjusted hazard ratios and %... Cohort, our dose-response meta-analysis provides a higher quality of the US - is! Family registry ): the pregnancy prognosis with either maternal or paternal reciprocal translocations is poorer than without.... And adverse pregnancy outcomes linkage study two explanations that may account for the poor prognosis [ 71.... And Fetal treatment Center - Ventriculomegaly, Giannakeas V, Sun P Narod! Hr of overall mortality Friedl a, Hussain ZH, Mohammed GH from summarized dose-response data was to! Epidemiology, prevention and public Health Chetver LL, Gallimidi Z, Stein ME, Kuten.. [ 10, 75 ], Kvalheim G, Kim HA HRs not!
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